Below is a list of the guests from episodes that were first aired or last repeated in 2016. To listen, click on the episode title to go to that episode’s page.
| Name | Discipline/Profession | Episode Title | Episode Date | Last Aired |
|---|---|---|---|---|
| Seth Abramovitch | Journalism/Technical Writing | Skeptic Check: How Low Can You Go? | 3/28/2016 | 6/25/2017 |
| Michael Abrams | Biology | The Fix is In | 8/3/2015 | 12/26/2016 |
| Mark Adams | Author | Hidden History | 3/30/2015 | 10/31/2016 |
| Peter Adams | Education | Skeptic Check: Skeptic Seth | 8/17/2015 | 9/26/2016 |
| Athena Aktipis | Evolutionary Sciences | Who’s Controlling Whom? | 10/13/2014 | 3/14/2016 |
| David Alexander | Earth Sciences/Ecology/Climate Change | Winging It | 1/18/2016 | 4/2/2017 |
| Stephon Alexander | Physics | Musical Universe | 7/25/2016 | 8/21/2017 |
| Colin Allen | History | Moral’s Law | 7/20/2015 | 10/24/2016 |
| Jonathan Amos | Journalism/Technical Writing | Surviving the Anthropocene | 2/23/2015 | 6/13/2016 |
| David Andrews | Author | Time Travel Agents | 10/17/2016 | 11/27/2017 |
| Jennifer Anne | Biology | DIY Diagnosis | 8/29/2016 | 12/25/2017 |
| Beth Archie | Biology | Microbes: Resistance is Futile | 3/16/2015 | 7/11/2016 |
| Daniel Armistead | Health/Medicine | Skeptic Check: Skeptic Seth | 8/17/2015 | 9/26/2016 |
| Dawn Balmer | Biology | Tale of the Distribution | 10/20/2014 | 4/4/2016 |
| John Barrett | Technology | Living Computers | 12/8/2014 | 5/2/2016 |
| Timothy Beers | Astronomy | And to Space We Return | 6/8/2015 | 11/7/2016 |
| Joshua Benoit | Biology | With All Our Mites | 2/15/2016 | 12/11/2017 |
| Emma Bentley | Other | Time Travel Agents | 10/17/2016 | 11/27/2017 |
| Bob Berman | Journalism/Technical Writing | Moving Right Along | 8/18/2014 | 4/18/2016 |
| Matt Bertone | Biology | With All Our Mites | 2/15/2016 | 12/11/2017 |
| Andre Bormanis | Author | Living Computers | 12/8/2014 | 5/2/2016 |
| Adrian Borsa | Physics | Land on the Run | 9/29/2014 | 3/7/2016 |
| Rob Brotherton | Psychology | Skeptic Check: Fear Itself | 12/21/2015 | 12/19/2016 |
| Michael Brown | Astronomy | 100% Invisible | 2/8/2016 | 5/15/2017 |
| Nathalie Cabrol | Planetary Science | A Stellar Job | 7/21/2014 | 1/4/2016 |
| Jose Carmena | Neuroscience | Replace What Ails You | 7/28/2014 | 1/25/2016 |
| Gene Cernan | Aeronautics/Space | Are We Over the Moon? | 8/15/2016 | 8/15/2016 |
| Manish Chamoli | Health/Medicine | Raising the Minimum Age | 4/6/2015 | 7/18/2016 |
| Marvin Chun | Psychology | They Know Who You Are | 5/18/2015 | 8/22/2016 |
| George Church | Genetics/Genomics | Raising the Minimum Age | 4/6/2015 | 7/18/2016 |
| Sharon Cisneros | Industry | Asteroids! | 9/5/2016 | 9/5/2016 |
| Jacob Corn | Genetics/Genomics | Gene-y in a Bottle | 3/21/2016 | 6/5/2017 |
| Paul Davies | Futurist | Skeptic Check: Aliens, the Evidence | 11/14/2016 | 9/25/2017 |
| Frans de Waal | Biology | Are Animals Really That Smart? | 12/12/2016 | 1/8/2018 |
| David DeSteno | Psychology | Moral’s Law | 7/20/2015 | 10/24/2016 |
| Shawn Douglas | Computer Science | The Fix is In | 8/3/2015 | 12/26/2016 |
| Dan Durda | Planetary Science | Are We Over the Moon? | 8/15/2016 | 8/15/2016 |
| John Dvorak | Earth Sciences/Ecology/Climate Change | Land on the Run | 9/29/2014 | 3/7/2016 |
| John Dvorak | Earth Sciences/Ecology/Climate Change | Caught in a Traps | 5/30/2016 | 7/31/2017 |
| David Eagleman | Neuroscience | Brain Dust | 12/5/2016 | 4/9/2018 |
| Douglas Emlen | Biology | Surfeit of the Vitalest | 11/17/2014 | 4/11/2016 |
| Michael Engel | Biology | On Defense | 8/1/2016 | 10/9/2017 |
| Juan Enriquez | Industry | The Evolution of Evolution | 5/4/2015 | 9/12/2016 |
| Brian Fagan | Anthropology | Apt to Adapt | 6/9/2014 | 1/11/2016 |
| Ed Finn | Education | Science Fiction | 5/16/2016 | 6/12/2017 |
| Andrew Fraknoi | Astronomy | Science Fiction | 5/16/2016 | 6/12/2017 |
| Richard Francis | Author | The Evolution of Evolution | 5/4/2015 | 9/12/2016 |
| J. L. Galache | Astronomy | Asteroids! | 9/5/2016 | 9/5/2016 |
| Greg Garrett | Humanities | Skeptic Check: After the Hereafter | 5/25/2015 | 8/8/2016 |
| Gordon Giesbrecht | Health/Medicine | Skeptic Check: How Low Can You Go? | 3/28/2016 | 6/25/2017 |
| Nada Gligorov | Health/Medicine | Microbes: Resistance is Futile | 3/16/2015 | 7/11/2016 |
| Lea Goentoro | Biology | The Fix is In | 8/3/2015 | 12/26/2016 |
| Thomas Goetz | Author | Replace What Ails You | 7/28/2014 | 1/25/2016 |
| Chris Goldfinger | Earth Sciences/Ecology/Climate Change | What Lies Beneath | 8/31/2015 | 6/12/2016 |
| Lee Goldman | Health/Medicine | Gene-y in a Bottle | 3/21/2016 | 6/5/2017 |
| Marc Goodman | Industry | They Know Who You Are | 5/18/2015 | 8/22/2016 |
| Jeff Gralnick | Biology | Shocking Ideas | 12/15/2014 | 5/9/2016 |
| Hank Greely | Law | Sex Post Facto | 9/19/2016 | 10/23/2017 |
| David Grinspoon | Astrobiology | Surviving the Anthropocene | 2/23/2015 | 6/13/2016 |
| Al Halloquist | Aeronautics/Space | Are We Over the Moon? | 8/15/2016 | 8/15/2016 |
| Al Harrison | Psychology | How to Talk to Aliens | 1/12/2015 | 6/6/2016 |
| Guy P. Harrison | Author | Skeptic Check: Skeptic Seth | 8/17/2015 | 9/26/2016 |
| Hank Heasler | Geology | Tale of the Distribution | 10/20/2014 | 4/4/2016 |
| Jessica Hellmann | Biology | The Evolution of Evolution | 5/4/2015 | 9/12/2016 |
| Brian Hoffman | Health/Medicine | On Defense | 8/1/2016 | 10/9/2017 |
| David Hughes | Biology | Who’s Controlling Whom? | 10/13/2014 | 3/14/2016 |
| Andy Ihnatko | Journalism/Technical Writing | Living Computers | 12/8/2014 | 5/2/2016 |
| Chris Impey | Astronomy | And to Space We Return | 6/8/2015 | 11/7/2016 |
| Walter Isaacson | Industry | Living Computers | 12/8/2014 | 5/2/2016 |
| Annie Jacobsen | Journalism/Technical Writing | On Defense | 8/1/2016 | 10/9/2017 |
| Kathleen Hall Jamieson | Journalism/Technical Writing | Skeptic Check: Science and the Election | 10/10/2016 | 10/10/2016 |
| Peter Jenniskens | Planetary Science | Asteroids! | 9/5/2016 | 9/5/2016 |
| Mike Joner | Astronomy | A Stellar Job | 7/21/2014 | 1/4/2016 |
| Morris Jones | Journalism/Technical Writing | How to Talk to Aliens | 1/12/2015 | 6/6/2016 |
| Tom Jordan | Earth Sciences/Ecology/Climate Change | Caught in a Traps | 5/30/2016 | 7/31/2017 |
| Simon Kattenhorn | Geology | Land on the Run | 9/29/2014 | 3/7/2016 |
| Katelynn Kazane | Genetics/Genomics | Gene-y in a Bottle | 3/21/2016 | 6/5/2017 |
| Christine Kenneally | Journalism/Technical Writing | Hidden History | 3/30/2015 | 10/31/2016 |
| Margee Kerr | Sociology | Skeptic Check: Fear Itself | 12/21/2015 | 12/19/2016 |
| Ali Khademhosseini | Biology | Replace What Ails You | 7/28/2014 | 1/25/2016 |
| Paul Kingsnorth | Journalism/Technical Writing | Apt to Adapt | 6/9/2014 | 1/11/2016 |
| Adam Korbitz | Law | Skeptic Check: The Me In Measles | 3/2/2015 | 6/27/2016 |
| Lawrence Krauss | Physics | Skeptic Check: Science and the Election | 10/10/2016 | 10/10/2016 |
| Ellen Langer | Psychology | Raising the Minimum Age | 4/6/2015 | 7/18/2016 |
| Michael Lemonick | Journalism/Technical Writing | 100% Invisible | 2/8/2016 | 5/15/2017 |
| Janna Levin | Physics | Musical Universe | 7/25/2016 | 8/21/2017 |
| Daniel Lieberman | Evolutionary Sciences | Apt to Adapt | 6/9/2014 | 1/11/2016 |
| Dana Lis | Health/Medicine | Skeptic Check: Glutenous Maximus | 2/1/2016 | 4/16/2017 |
| Gordon Lithgow | Genetics/Genomics | Raising the Minimum Age | 4/6/2015 | 7/18/2016 |
| Alex Liu | Biology | Are Animals Really That Smart? | 12/12/2016 | 1/8/2018 |
| Seth Lloyd | Engineering | Time Travel Agents | 10/17/2016 | 11/27/2017 |
| John Logsdon | Aeronautics/Space | Are We Over the Moon? | 8/15/2016 | 8/15/2016 |
| Jake Lowenstern | Geology | Tale of the Distribution | 10/20/2014 | 4/4/2016 |
| Owen Maercks | Biology | Venom Diagram | 10/3/2016 | 10/30/2017 |
| Michel Maharbiz | Engineering | Brain Dust | 12/5/2016 | 4/9/2018 |
| Brian Malow | Entertainment | Science Fiction | 5/16/2016 | 6/12/2017 |
| Jason Mark | Journalism/Technical Writing | Science Fiction True | 12/22/2013 | 7/4/2016 |
| Cliff Mass | Earth Sciences/Ecology/Climate Change | Weather Vain | 11/21/2016 | 1/1/2018 |
| Andrew Maynard | Sociology | Skeptic Check: Skeptic Seth | 8/17/2015 | 9/26/2016 |
| Andrew Maynard | Sociology | Tale of the Distribution | 10/20/2014 | 4/4/2016 |
| Andrew Maynard | Sociology | Skeptic Check: The Me In Measles | 3/2/2015 | 6/27/2016 |
| Thomas McDade | Anthropology | With All Our Mites | 2/15/2016 | 12/11/2017 |
| Arthur McDonald | Astronomy | 100% Invisible | 2/8/2016 | 5/15/2017 |
| Bill Miller | Health/Medicine | Microbes: Resistance is Futile | 3/16/2015 | 7/11/2016 |
| Steven Miller | Earth Sciences/Ecology/Climate Change | Weather Vain | 11/21/2016 | 1/1/2018 |
| Mark Miodownik | Technology | The Fix is In | 8/3/2015 | 12/26/2016 |
| Ross Mitchell | Geology | Land on the Run | 9/29/2014 | 3/7/2016 |
| Sarah Moffitt | Earth Sciences/Ecology/Climate Change | The Fix is In | 8/3/2015 | 12/26/2016 |
| Peter Moore | Author | Weather Vain | 11/21/2016 | 1/1/2018 |
| David Morrison | Planetary Science | Hidden History | 3/30/2015 | 10/31/2016 |
| David Morrison | Planetary Science | Asteroids! | 9/5/2016 | 9/5/2016 |
| RIchard Muller | Physics | Time Travel Agents | 10/17/2016 | 11/27/2017 |
| William Murphy | Health/Medicine | Replace What Ails You | 7/28/2014 | 1/25/2016 |
| Clive Neal | Geology | The Crater Good | 2/29/2016 | 5/29/2017 |
| Steven Novella | Neuroscience | Skeptic Check: Skeptic Seth | 8/17/2015 | 9/26/2016 |
| Steven Novella | Neuroscience | Skeptic Check: After the Hereafter | 5/25/2015 | 8/8/2016 |
| James Oberg | Aeronautics/Space | The Crater Good | 2/29/2016 | 5/29/2017 |
| Paul Offit | Health/Medicine | Skeptic Check: The Me In Measles | 3/2/2015 | 6/27/2016 |
| Shawn Lawrence Otto | Author | Skeptic Check: Science and the Election | 10/10/2016 | 10/10/2016 |
| Mitesh Patel | Health/Medicine | Skeptic Check: Glutenous Maximus | 2/1/2016 | 4/16/2017 |
| Roland Pease | Journalism/Technical Writing | Elements Never Forget | 6/20/2016 | 8/28/2017 |
| William Phillips | Physics | Moving Right Along | 8/18/2014 | 4/18/2016 |
| Siddha Pimputkar | Materials Science | Shocking Ideas | 12/15/2014 | 5/9/2016 |
| Kara Platoni | Journalism/Technical Writing | Eve of Disruption | 2/22/2016 | 5/1/2017 |
| Patrick Porter | Other | Surviving the Anthropocene | 2/23/2015 | 6/13/2016 |
| Donald Prothero | Geology | Tale of the Distribution | 10/20/2014 | 4/4/2016 |
| Cassandra Quave | Biology | Venom Diagram | 10/3/2016 | 10/30/2017 |
| Margaret Race | Biology | The Crater Good | 2/29/2016 | 5/29/2017 |
| Ben Radford | Sociology | Skeptic Check: After the Hereafter | 5/25/2015 | 8/8/2016 |
| Ben Radford | Sociology | Skeptic Check: Aliens, the Evidence | 11/14/2016 | 9/25/2017 |
| Steve Ramirez | Neuroscience | Science Fiction True | 12/22/2013 | 7/4/2016 |
| Lisa Randall | Physics | 100% Invisible | 2/8/2016 | 5/15/2017 |
| Sarah Ratley | Aeronautics/Space | Are We Over the Moon? | 8/15/2016 | 8/15/2016 |
| Rob Rhinehart | Industry | Science Fiction True | 12/22/2013 | 7/4/2016 |
| Mark Richards | Planetary Science | Caught in a Traps | 5/30/2016 | 7/31/2017 |
| Robert Richards | Industry | Are We Over the Moon? | 8/15/2016 | 8/15/2016 |
| Christina Richey | Planetary Science | Asteroids! | 9/5/2016 | 9/5/2016 |
| Mary Roach | Author | On Defense | 8/1/2016 | 10/9/2017 |
| Paul Robertson | Planetary Science | A Stellar Job | 7/21/2014 | 1/4/2016 |
| Bruce Robison | Biology | What Lies Beneath | 8/31/2015 | 6/12/2016 |
| Alan Robock | Earth Sciences/Ecology/Climate Change | Weather Vain | 11/21/2016 | 1/1/2018 |
| Alec Ross | Technology | Eve of Disruption | 2/22/2016 | 5/1/2017 |
| Mike Rubenstein | Robotics/IA | Who’s Controlling Whom? | 10/13/2014 | 3/14/2016 |
| Michael Ruhlman | Author | Skeptic Check: Glutenous Maximus | 2/1/2016 | 4/16/2017 |
| William Sager | Physics | What Lies Beneath | 8/31/2015 | 6/12/2016 |
| Adam Savage | Entertainment | Skeptic Check: Busting Myths with Adam Savage | 5/23/2016 | 8/7/2017 |
| Menno Schilthuizen | Biology | Sex Post Facto | 9/19/2016 | 10/23/2017 |
| Justin Schmidt | Biology | Venom Diagram | 10/3/2016 | 10/30/2017 |
| Julia Scott | Journalism/Technical Writing | Microbes: Resistance is Futile | 3/16/2015 | 7/11/2016 |
| Michael Shermer | Journalism/Technical Writing | Moral’s Law | 7/20/2015 | 10/24/2016 |
| Grant Shoffstall | Sociology | Skeptic Check: How Low Can You Go? | 3/28/2016 | 6/25/2017 |
| Peter Simpson-Young | Neuroscience | DIY Diagnosis | 8/29/2016 | 12/25/2017 |
| Sanjiv Singh | Robotics/IA | Winging It | 1/18/2016 | 4/2/2017 |
| Beth Skwarecki | Journalism/Technical Writing | Skeptic Check: Glutenous Maximus | 2/1/2016 | 4/16/2017 |
| Cameron Smith | Anthropology | And to Space We Return | 6/8/2015 | 11/7/2016 |
| Michael Smith | Earth Sciences/Ecology/Climate Change | Moving Right Along | 8/18/2014 | 4/18/2016 |
| Bruce Sterling | Author | Science Fiction | 5/16/2016 | 6/12/2017 |
| Mark Stoyer | Chemistry | Elements Never Forget | 6/20/2016 | 8/28/2017 |
| Alex Tabarrok | Economics | Asteroids! | 9/5/2016 | 9/5/2016 |
| Jill Tarter | Astronomy | Skeptic Check: Aliens, the Evidence | 11/14/2016 | 9/25/2017 |
| Kevin Tracey | Health/Medicine | Shocking Ideas | 12/15/2014 | 5/9/2016 |
| Michelle Trautwein | Biology | With All Our Mites | 2/15/2016 | 12/11/2017 |
| Abigail Tucker | Author | Are Animals Really That Smart? | 12/12/2016 | 1/8/2018 |
| Merlin Tuttle | Earth Sciences/Ecology/Climate Change | Winging It | 1/18/2016 | 4/2/2017 |
| Neil deGrasse Tyson | Astronomy | Skeptic Check: The Me In Measles | 3/2/2015 | 6/27/2016 |
| Douglas Vakoch | Sociology | How to Talk to Aliens | 1/12/2015 | 6/6/2016 |
| Francisco Valero | Physics | Surviving the Anthropocene | 2/23/2015 | 6/13/2016 |
| Gaia Vince | Journalism/Technical Writing | Surviving the Anthropocene | 2/23/2015 | 6/13/2016 |
| Inna Vishik | Physics | Elements Never Forget | 6/20/2016 | 8/28/2017 |
| Christopher Voigt | Biology | Living Computers | 12/8/2014 | 5/2/2016 |
| Wendell Wallach | Biology | Who’s Controlling Whom? | 10/13/2014 | 3/14/2016 |
| Susan Walsh | Genetics/Genomics | They Know Who You Are | 5/18/2015 | 8/22/2016 |
| Peter Ward | Biology | Hidden History | 3/30/2015 | 10/31/2016 |
| Paul Wason | Anthropology | How to Talk to Aliens | 1/12/2015 | 6/6/2016 |
| Duncan Wass | Chemistry | Winging It | 1/18/2016 | 4/2/2017 |
| Matthew Webster | Evolutionary Sciences | Sex Post Facto | 9/19/2016 | 10/23/2017 |
| Eric Weiner | Author | Eve of Disruption | 2/22/2016 | 5/1/2017 |
| Shari Wells-Jensen | Humanities | How to Talk to Aliens | 1/12/2015 | 6/6/2016 |
| Anna Wexler | Neuroscience | DIY Diagnosis | 8/29/2016 | 12/25/2017 |
| Christie Wilcox | Author | Venom Diagram | 10/3/2016 | 10/30/2017 |
| Bernard Wood | Anthropology | Surfeit of the Vitalest | 11/17/2014 | 4/11/2016 |
| Edward Young | Chemistry | The Crater Good | 2/29/2016 | 5/29/2017 |
| Jeffrey Zacks | Neuroscience | Science Fiction True | 12/22/2013 | 7/4/2016 |
| Josiah Zayner | Biology | Gene-y in a Bottle | 3/21/2016 | 6/5/2017 |
| Anthony Zee | Physics | A Stellar Job | 7/21/2014 | 1/4/2016 |
| Carl Zimmer | Journalism/Technical Writing | Surfeit of the Vitalest | 11/17/2014 | 4/11/2016 |
| Carl Zimmer | Journalism/Technical Writing | DIY Diagnosis | 8/29/2016 | 12/25/2017 |
| Marlene Zuk | Evolutionary Sciences | Apt to Adapt | 6/9/2014 | 1/11/2016 |
